Animal copy experiments haven't been executed Together with the drug combination-promethazine and codeine. It's not acknowledged whether or not this drug mix can cause fetal hurt when administered to some pregnant woman or can have an affect on reproduction capacity.

The most common Unintended effects are drowsiness, modifications in hypertension, skin reactions, blood cell adjustments and respiratory complications. Greater excitability or abnormal actions may take place just after one dose of promethazine. Whenever they do, consult your health practitioner about using A further drugs.

Your healthcare provider may possibly do blood assessments to look for adrenal gland troubles. Connect with your healthcare company instantly In case you have any of these signs and symptoms:

Promethazine is nicely absorbed in the gastrointestinal tract. Scientific outcomes are obvious inside twenty minutes just after oral administration and usually final 4 to six several hours, While they may persist as long as 12 several hours.

For preoperative medication young children call for doses of 0.5 mg per pound of entire body fat in combination with the appropriately lessened dose of narcotic or barbiturate and the right dose of an atropine-like drug.

Due to the fact recurrences of NMS have been noted with phenothiazines, the reintroduction of promethazine HCl ought to be very carefully deemed.

Promethazine check here HCl can be employed by itself or as an adjunct to narcotic analgesics throughout labor (see DOSAGE AND ADMINISTRATION). Restricted facts propose that usage of Promethazine in the course of labor and shipping doesn't have an appreciable effect on the length of labor or shipping and does not raise the hazard of require for intervention from the new child.

Recommend individuals to normally use an correct milliliter measuring machine when measuring and administering Promethazine HCl and Codeine Phosphate Oral Remedy. Advise individuals that a domestic teaspoon just isn't an precise measuring gadget and these use could lead to overdosage and significant adverse reactions [see Overdosage (ten)].

Labor or Shipping and delivery Opioids cross the placenta and should deliver respiratory depression and psycho-physiologic results in neonates. An opioid antagonist, for instance naloxone, should be readily available for reversal of opioid-induced respiratory melancholy during the neonate.

It's difficult to ascertain what constitutes a regular harmful or lethal dose. Nonetheless, the lethal oral dose of codeine within an Grownup is claimed for being from the array of 0.

The effect of promethazine and/or codeine on later on development and advancement of the newborn is mysterious.

This may be worsened if taken with Liquor or other medicines that also cause central nervous procedure (CNS) slowing for instance sedatives, soreness medicines, tranquilizers or sure medications for melancholy.

The causal part of opioids during the medical syndrome of hypogonadism is unknown as the different health-related, physical, Way of life, and psychological stressors that will impact gonadal hormone levels have not been adequately controlled for in scientific studies executed to this point [see Adverse Reactions (six)].

Nevertheless, codeine must be administered only less than near supervision to individuals with a record of drug abuse or dependence.